Volume 13, Issue 4 (2017) | American Journal of Immunology

Involvement of the α/β Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5)

Anwar M Hasan — 2017-10-26

American Journal of Immunology, Published online: 26 October 2017; doi:10.3844/ajisp.2017.209.215

Eosinophils are the principal effector cells for allergic inflammation in a variety of diseases, in which they contribute to tissue damage and remodelling processes via the secretion of cytotoxic gran...

The Arid3a Transcription Factor Rescues Natural and RAS-V12-Induced Senescence Via a Rb-Dependent Pathway

Christian Schmidt — 2017-11-04

American Journal of Immunology, Published online: 4 November 2017; doi:10.3844/ajisp.2017.216.232

Primary cells are protected against oncogenic events by undergoing premature cellular senescence—an irreversible cell cycle arrest activated by mitogenic signaling as well as by overexpression of tu...

The Triple Immune Argument; Surveillance/Evasion/ Senescence and the Increased Incidence of Acute Myeloid Leukemia Observed with Age

Manar M. Ismail — 2017-12-22

American Journal of Immunology, Published online: 22 December 2017; doi:10.3844/ajisp.2017.233.252

AML originates from genetic insults of hematopoietic stem and progenitor cells (HSPCs/HSCs) that was identified earlier as leukemia stem cells (LSCs). In quiescent state, trafficking immune cells are ...